LSU, Louisville, USC headline college football favorites in Week 12

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Six weeks and a coaching change later, the LSU Tigers are probably better equipped to take on the Florida Gators.

The Tigers are the 13.5-point favorite at sportsbooks monitored by OddsShark.com against the banged-up Gators in a matchup that was rescheduled due to Hurricane Matthew. The visiting team is 1-4 straight-up and against the spread in the last five editions of this matchup, while LSU is 2-7 ATS in its last nine games in Week 12.

Since Ed Orgeron became interim coach after Les Miles’ termination, the Tigers are 4-1 SU. The Tigers suffered a shutout loss against No. 1 Alabama in their last home outing, but are 13-0 SU at Tiger Stadium after losing their previous home game.

The Gators are banged-up with OLB Alex Anzalone, MLB Jarrad Davis and S Marcus Maye sidelined, which might help LSU in a battle of attrition. Primary RB Leonard Fournette (ankle) has aggravated an injury, but Derrius Guice is a capable understudy.

In a Thursday game, Heisman Trophy favorite Lamar Jackson and the Louisville Cardinals are favored by 14.5 on the road against the Houston Cougars. Houston has a quick defensive front that stands a good chance at turning Jackson into a pocket passer. Cougars QB Greg Ward Jr. (shoulder) has been playing hurt recently, but with defensive leaders such as ILB Keith Kelsey and CB Jaire Alexander, Louisville should avoid a total collapse.

The Oklahoma Sooners are the 2.5-point road favorite against the West Virginia Mountaineers. Sooners QB Baker Mayfield is more consistent than WVU counterpart Skyler Howard, and has game-breaking WR Dede Westbrook to help extend a 14-game conference win streak. West Virginia and S Kyzir White have won – by Big 12 standards – some tight defensive battles, but doing that against the Sooners might be daunting.

The TCU Horned Frogs are favored by 4.5 points against the Oklahoma State Cowboys. The Frogs are coming off a bye week and QB Kenny Hill will be complemented by now healthy starters such as WR Deante Gray, G Patrick Morris and WR/KR KaVontae Turpin. Oklahoma State’s Mason Rudolph will also face a good TCU pass rush. The home team has won all of the teams’ meetings since the Frogs joined the Big 12 in 2012.

The Colorado Buffaloes are also favored by 4.5 against the Washington State Cougars in a showdown between the Pac-12’s unlikely divisional leaders. The visiting team is 5-1 ATS in the last six editions of the matchup. Colorado is in the top 10 in the country in scoring defense, but shutting down QB Luke Falk and the Cougars’ Air Raid attack for 60 minutes could be daunting.

And the USC Trojans are favored by 12 against the cross-town rival UCLA Bruins. The line might be inflated in USC’s favor since it is fresh off defeating Washington, but QB Sam Darnold is backed up by a reliable rushing attack and Bruins QB Mike Fafaul is not. The Trojans are  2-5 SU and 1-6 ATS in their last seven road games after winning their most recent road game, but CB Adoree’ Jackson gives them greater capability of inducing game-changing turnovers.

Louisville vs. Wake Forest college football, live online stream

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No. 6 Louisville (8-1 6-1 ACC) tries to continue to make its case for the College Football Playoff as it faces Wake Forest (6-3, 3-2 ACC) at BB&T Field.

Louisville QB Lamar Jackson has been the clear Heisman favorite so far this season and looks to add on to his campaign after a running for 3 touchdowns and throwing for 4 more in the Cardinals 52-7 win over Boston College.

Wake Forest comes off of a 27-20 win against Virginia led by QB Jake Wafford who rushed for 94 yards and 1 TD and threw for 83 yards and 1 TD.

Watch the game live here:

When: 7:00 pm

Broadcast Network: ESPN

Live Stream:ESPN.com