Notre Dame joins Clemson, Ole Miss as college football favorites in Week 4

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Now out of College Football Playoff contention, DeShone Kizer and the Notre Dame Fighting Irish face a trap game on Saturday against the Duke Blue Devils, who are a proven success at being a tough underdog.

Notre Dame is listed as a 21-point favorite against Duke, with total of 59.5 points, at sportsbooks monitored by OddsShark.com. Notre Dame is only 3-7 against the spread in their last 10 games after a loss, according to the OddsShark College Football Database. Duke is 13-4 straight-up and 12-5 ATS in its last 17 road games.

The Clemson Tigers are 9.5-point road favorites against the Georgia Tech Yellow Jackets, with a total of 57.5 ahead of their Thursday matchup. Clemson is 2-7 ATS in its last nine road games. Georgia Tech is 1-7 SU and ATS in its last eight games against teams with winning records.

The Michigan State Spartans are 5.5-point favorites, with a total of 57.5, against the Wisconsin Badgers. Wisconsin is 3-8 ATS in its last 11 games vs. Big Ten counterparts.  The Spartans are 11-1 SU and 7-5 ATS in conference home games since 2013.

The Michigan Wolverines are 19-point betting favorites against the Penn State Nittany Lions, with a total of 58. Penn State is 1-6 SU in its last seven road games vs. Michigan. The Wolverines are 6-1 ATS in their last seven games after an ATS loss.

The Mississippi Rebels are seven-point favorites against the Georgia Bulldogs, with a total of 60. Georgia is 0-5 ATS in its last five games on the road after consecutive wins on the road. Mississippi is 7-0 SU in its last seven games after a loss.

The Tennessee Volunteers are favored by 6.5 points against the rival Florida Gators. The total is 43.5. Florida is 10-4 ATS in its last 14 games against teams with winning records. Tennessee is 1-5 ATS in its last six games in Week 4.

In a neutral site game at AT&T Stadium in Arlington, the Texas A&M Aggies are a 5.5-point favorite against the Arkansas Razorbacks, with a total of 49. Arkansas is 0-10 SU after losing the previous game in a matchup, but is 5-2 ATS in its last seven games vs. Texas A&M.

The Florida State Seminoles are six-point favorites against the South Florida Bulls, with a total of 61. Florida State is 9-3 ATS in its last 12 games on the road after a loss on the road. South Florida is 7-1 ATS in its last eight games in September.

The Stanford Cardinal are a three-point road favorite against the UCLA Bruins, with a total of 46. Stanford is 12-1 SU and 11-2 ATS in its last 13 conference games.