Week 3 College Football Odds: Notre Dame Favored vs Nemesis Michigan State

Getty Images

The Notre Dame Fighting Irish aim to maintain their winning ways at home this weekend, but the Michigan State Spartans have had their number over the years.

Notre Dame are listed as 7.5-point favorites with a total of 52 in a Top 20 matchup against Michigan State at sportsbooks monitored by OddsShark.com.

Notre Dame is 7-0 straight-up and 6-1 against the spread over its last seven home games, according to the OddsShark College Football Database. The Irish are 8-2 ATS over their last 10 games against teams with winning records. Michigan State is 7-1-1 ATS in its last nine road games against Notre Dame.

Alabama coach Nick Saban has not lost to a team three seasons in a row since he was at Michigan State in the 1990s. The top-ranked Crimson Tide are 11-point favorites for their rematch against the Mississippi Rebels, with a 54.5-point total. Alabama is 7-2 ATS in its last nine games when coming off consecutive wins. Mississippi is 5-0 SU in its last five games against teams with  winning records.

The Florida State Seminoles are a two-point betting favorite against the Louisville Cardinals with a total of 65.5. Florida State is 3-1 SU in its last four games vs. Louisville, and 5-2 ATS during its last seven road games. Louisville is 12-2 SU in its last 14 games after losing the previous game in a matchup.

The Ohio State Buckeyes, in their first serious test, are 1.5-point favorites against the  Oklahoma Sooners. The Buckeyes have won 18 road games in a row, and are 10-4 ATS in their last 14 September games. The Sooners are 7-3 ATS in their last 10 September games.

With star QB Greg Ward Jr. slated to return from injury, the Houston Cougars are 7.5-point favorites against the Cincinnati Bearcats entering their Thursday game. The total is 64. Houston is 14-1-1 ATS over its last 16 road games.

The Stanford Cardinal are nine-point favorites against the USC Trojans, with a total of 53. Stanford is 10-0 SU and 9-1 ATS in its last 10 games after winning the previous game in a matchup. Southern Cal is 2-6 SU in its last eight games against Stanford.

The Nebraska Cornhuskers are three-point favorites at home against the Oregon Ducks, with a total of 73. The Cornhuskers are 6-2 ATS in their last eight Week 3 games. Oregon is 6-1 SU and ATS in its last seven games against teams with winning records.

The Auburn Tigers are 3.5-point favorites at home against the Texas A&M Aggies with a total of 52.5. The visiting team is 4-0 SU and ATS in the last four games in this matchup. Auburn is only 3-9 SU in its last 12 games against teams with winning records.