16-1 shot Melatonin scores upset in $1M Santa Anita Handicap

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ARCADIA, Calif.¬†—¬†Longshot Melatonin won the $1 million Santa Anita Handicap by 4 1/2 lengths.

Ridden by Joe Talamo, Melatonin ran 1 1/4 miles in 2:02.01 and paid $34.60, $13.80 and $6 at 16-1 odds on Saturday.

Hard Aces returned $19.20 and $7.20, while 7-5 favorite Effinex was another half-length back in third and paid $2.80 to show.

Effinex, a forgotten second to Triple Crown winner American Pharoah in the $5 million Breeders’ Cup Classic last fall, had been idle since winning the Clark Handicap at Churchill Downs on Nov. 27.

Trained by David Hofmans, Melatonin was coming off a 3 3/4-length victory at Santa Anita last month. He earned $600,000 for the win, his fourth in 11 career starts.