With big College Football Playoff stakes attached, the Clemson Tigers are a slight underdog at home against the Louisville Cardinals on Saturday.
Louisville is listed as a two-point favorite against fellow unbeaten Clemson with a total of 67.5, according to sportsbooks monitored by OddsShark.com. The Tigers have won 18 home games in a row. They are 9-1 straight-up and 4-6 against the spread in their last 10 October home games, according to the OddsShark College Football Database.
Louisville, which is 0-2 SU and 2-0 ATS vs. Clemson since joining the ACC, is 10-2 SU in its last 12 games after losing the previous game in a matchup.
The Washington Huskies are three-point favorites, with a total of 44, against the Stanford Cardinal in a Friday game. Stanford is 7-1 SU in its last eight games against Washington. Washington is 7-0 SU and 5-2 ATS in its last seven games.
The Michigan Wolverines are favored by 10.5 points, with a total of 45, against the Wisconsin Badgers. Michigan is 9-1 SU and 6-4 ATS over its last 10 games as a favorite of 7.5 to 14 points. Wisconsin carries a 7-1-1 ATS trend against Michigan.
The Notre Dame Fighting Irish are favored by 10 against the Syracuse Orange, with a total of 75. Notre Dame is 1-3 ATS in its last four games vs. Syracuse. Syracuse is 5-2 ATS in its last seven games.
Coming off a loss to Wisconsin, the Michigan State Spartans are seven-point favorites against the Indiana Hoosiers. Michigan State is 6-0 SU and 5-1 ATS in its last six games after a loss. Indiana is 1-7 SU in its last eight games against teams with winning records.
The Tennessee Volunteers are 3.5-point road favorites against the Georgia Bulldogs, with a total of 53. Tennessee is 1-5 SU in its last six games against Georgia. Georgia is 1-6-1 ATS in its last eight games in Week 5.
The Florida State Seminoles are favored by 11 against the North Carolina Tar Heels, with a total of 70. The Seminoles are 7-3 ATS in their last 10 games. North Carolina is 2-9 SU in its last 11 games against FSU.
The Oklahoma Sooners are 3.5-point favorites against the TCU Horned Frogs, with a total of 69.5. Oklahoma is 4-1 SU in its last five games against TCU, including a 2015 home win. The Horned Frogs are 7-0 SU in their last seven games after losing the previous game in a matchup.
And the Oklahoma State Cowboys are 2.5-point favorites against the Texas Longhorns, with a total of 71.5. Oklahoma State is 1-5 SU and ATS in its last six games against teams with winning records. Texas is 14-4 SU in its last 18 games vs. OSU.