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Serena Williams defeated in U.S. Open semis by Karolina Pliskova

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  — Serena Williams was upset in the U.S. Open semifinals for the second year in a row, beaten 6-2, 7-6 (5) by 10th-seeded Karolina Pliskova of the Czech Republic on Thursday night.

Williams, who clutched at her left leg between points in the second set, double-faulted to end it.

Afterward, her coach, Patrick Mouratoglou, said Williams injured her left knee in the quarterfinals.

The loss prevents Williams from earning her seventh championship at Flushing Meadows and 23rd major title overall, which would both have been Open-era records.

It also means Williams’ 3½-year reign at No. 1 in the WTA rankings will end. She will be overtaken on Monday by current No. 2 Angelique Kerber, who was to face Caroline Wozniacki in Thursday’s second semifinal.

A year ago, Williams’ bid for a calendar-year Grand Slam ended when she lost in the U.S. Open semifinals to unseeded Roberta Vinci of Italy in the semifinals.

This was the 33rd major semifinal of Williams’ career, and the first for Pliskova, who beat the 34-year-old American’s older sister Venus in the fourth round. Pliskova is only the fourth woman to beat both Williams siblings during the same Grand Slam tournament.

And to think: The 24-year-old Pliskova had never been past the third round in 17 previous appearances at majors.

But on Thursday, she certainly looked the part of an up-and-comer with the strokes and demeanor to go far.

The temperature was in the low 80s, and the air was muggy and still, and Williams kept using the pleats of her black-and-pink skirt to wipe her sweaty palms between points.

Watching Williams miss shot after shot — 31 unforced errors in all — one couldn’t help but wonder why.

One thought: Maybe it was a recurrence of the soreness in her right shoulder that became bothersome in the days right after she won singles and doubles titles at Wimbledon two months ago. Or perhaps it was the toll of the grueling three-set quarterfinal against Simona Halep that concluded less than 22 hours before the semifinal started. But by the latter stages, Williams kept reaching for her left leg.

“She was not moving at all today,” Mouratoglou said. “There was no match.”

Still, Pliskova surely had a lot to do with Williams’ woes. Pliskova’s power is of the sort that Williams so rarely is forced to confront — much like the difficulties the American’s own game presents others.

Pliskova serves well, leading the tour in aces this season, and her angled offerings gave Williams fits. She also returns well, often sending stinging responses right at Williams’ feet, leaving her no time to react properly. And when they engaged in lengthy baseline exchanges, Pliskova’s deep, flat groundstrokes were able to produce the rare sight of Williams back on her heels.

All of 7 minutes in, Pliskova showed she was not shaken by any of it — the stage, the setting, the stakes or the foe — and was going to make this a struggle for Williams. Getting all sorts of pace on returns, including on a 104 mph serve at break point, when Williams sent a backhand long to trail 2-1.

Williams yelled out, “Ai-yai-yai!” and slapped her left thigh.

Pliskova broke again, this time at love, to lead 5-2 thanks to a double-fault and a trio of miscues by Williams. That was part of a stretch in which Pliskova grabbed 10 of the first set’s last 11 points.

Not much later, things were looking decidedly dicey for Williams when she sailed a backhand long to get broken and trail 3-2 in the second. Pliskova, who betrayed little emotion otherwise on this evening, leaned over and pumped her fists.

They had played for 46 minutes, and it was clear who was better. Pliskova sat in her changeover seat, leaned back and exhaled. And then, for the very first time, she showed some nerves, coming out and playing her shakiest game of the match to get broken at love.

Into the tiebreaker they went, and Pliskova jumped ahead 3-0. Then came Williams, never one to back down, going ahead 5-4, just two points from forcing a third set. But she wouldn’t take another point, closing the surprising loss with a sixth double-fault and leaving Flushing Meadows with another disappointment.

Andy Murray, Angelique Kerber out in 4th round of Australian Open

2017 Australian Open - Day 7
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MELBOURNE, Australia (AP) There was some symmetry about the fourth-round exits of top-ranked Andy Murray and Angelique Kerber at the Australian Open.

Both had the top seeding for the first time at a Grand Slam tournament. Both went out on the same court and, at least on paper, the same day.

It was tough at the top on Sunday: Five-time finalist Murray lost 7-5, 5-7, 6-2, 6-4 to No. 50-ranked Mischa Zverev in the afternoon match on Rod Laver Arena, and defending women’s champion Kerber lost 6-3, 6-2 to CoCo Vandeweghe in an upset that finished at six minutes past midnight.

It was the first time since the French Open in 2010 that both top-seeded players went out in the same round. In the quarterfinals at Roland Garros that year, Roger Federer lost to Robin Soderling and Serena Williams lost to Sam Stosur.

Murray and Kerber didn’t make it to the second week.

Vandeweghe had never been past the third round at the season-opening Grand Slam, and lost in the first round here last year. But she pounded Kerber with a powerful forehand, clubbing 13 of her 30 winners from that wing.

Kerber saved a match point in the first round last year before winning her first major title, beating Serena Williams in the final. She replaced Williams atop the rankings after winning the U.S. Open.

Murray lost the final here to six-time champion Novak Djokovic last year, but finished 2016 at No. 1 after a strong finish to the season that included titles at Wimbledon, the Olympics and the ATP Finals.

He was undone by some old-school serve and volley from Zverev, who played the match of his life. He’ll now meet 17-time major winner Federer in the quarterfinals.

In between the upsets was pretty rocky, too. Federer was down 5-1 in the first set against Kei Nishikori but found a way to fend off the 2014 U.S. Open finalist, who was cramping and needed late treatment on his back, 6-7 (4), 6-4, 6-1, 4-6, 6-3.

It was his 200th career win over a top 10 player.

Federer was ecstatic. “It was about staying with him. … almost going down 6-0, I thought `It’s not going to get any worse from there,'” said Federer, on the comeback from six months on the sidelines to repair his injured left knee. “Huge win for me in my career.”

Murray was stunned.

“Right now I’m obviously very down because I wanted to go further in this event,” Murray said. “I’ve had tough losses in my career in the past. I’ve come back from them. This is a tough one.”

Murray’s exit follows the second-round departure of Djokovic, beaten in the second round by No. 117-ranked wild-card entry Denis Istomin.

It’s the first time since 2002 that the top two seeds in the men’s draw haven’t reached the Australian Open quarterfinals, and the first time at a Grand Slam since the French Open in 2004.

The absence of Djokovic and Murray certainly opens up it up for others.

U.S. Open champion Stan Wawrinka, who had his major breakthrough here in 2014, is a growing contender after beating Andreas Seppi 7-6 (2), 7-6 (4), 7-6 (4). He’ll play a quarterfinal against 2008 Australian Open finalist Jo-Wilfried Tsonga, who beat Dan Evans 6-7 (4), 6-2, 6-4, 6-4.

In the bottom half of the draw, 14-time major winner Rafael Nadal is the only man still in contention who has won a Grand Slam title.

The top half of the women’s draw is open, too. Venus Williams returned to the quarterfinals for the ninth time with a 6-3, 7-5 win over No. 181-ranked Mona Barthel.

The seven-time major winner next plays No. 24-seeded Anastasia Pavlyuchenkova, who beat No. 8 Svetlana Kuznetsova 6-3, 6-3.

French Open champion Garbine Muguruza beat Sorana Cirstea 6-2, 6-3 and will next play Vandeweghe – they’re both in the quarterfinals at Melbourne Park for the first time.

Kerber’s loss contined a poor run since she won the U.S. Open last September. She’s played seven tournaments without winning a title, only reached one final, and was 5-7 against top 50 players.

The bigger upset of the day, then, was produced by Zverev, the older and apparently lesser-talented brother of Alexander who had never gone past the third round of a major and was appearing at only his third Grand Slam in six years.

Zverev attacked Murray, unsettling his natural baseline game, and won 65 of 118 points at the net.

He made some stunning, lunging volleys on clutch points, but for him it was all a blur.

“It was like I was in a little coma, I just served and volleyed my way through,” Zverev said. “Honestly there were a few points where I don’t know how I pulled it off.”

Murray couldn’t do a lot to counter it.

“It’s the shots he was coming up with when he did come forward.” Murray said. “He came up with some great pickups, you know, reflex volleys especially at the end when it was tight.”

Murray had reached the quarterfinals or better on his previous seven trips to Australia but never won the title – losing finals in 2010 to Federer and in `11, `13, `15 and `16 to Djokovic.

He had not lost to a player ranked as lowly as Zverev at a major since his loss to No. 51 Juan Ignacio Chela here in 2006. It was also the earliest exit by a top-seeded player at the Australian Open since Lleyton Hewitt in 2003.

Murray out in 4th-round upset, Federer advances in Australia

2017 Australian Open - Day 7
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MELBOURNE, Australia (AP) Andy Murray had already been upset by Mischa Zverev, undone by some old-school serve and volley, and Roger Federer was down 5-1 in the first set against Kei Nishikori.

As Sunday stretched from afternoon to evening, the second week of the Australian Open appeared set to take on a drastically different complexion than any in a decade.

Unlike newly-installed No. 1 Murray, though, the long-time top-ranked Federer found a way to fend off his fourth-round rival.

The sum result of back-to-back long matches on Rod Laver Arena was a quarterfinal pairing of 17th-seeded Federer against No. 50-ranked Zverev.

Five-time finalist Murray lost in a 7-5, 5-7, 6-2, 6-4 to Zverev, the older and apparently lesser-talented brother of Alexander who had never gone past the third round of a major and was appearing at only his third Grand Slam in six years.

Federer held off 2014 U.S. Open finalist Nishikori, who was cramping and needed late treatment on his back, 6-7 (4), 6-4, 6-1, 4-6, 6-3.

Murray’s exit follows the second-round departure of six-time defending champion Novak Djokovic, beaten in the second round by No. 117-ranked wild-card entry Denis Istomin.

It’s the first time since 2002 that the top two seeds haven’t reached the Australian Open quarterfinals, and the first time at a Grand Slam since the French Open in 2004.

“Right now I’m obviously very down because I wanted to go further in this event, and it wasn’t to be,” Murray said. “I’ve had tough losses in my career in the past. I’ve come back from them. This is a tough one. I’m sure I’ll come back OK.”

The absence of Djokovic and Murray from the quarterfinals – the first time since 2007 that at least one of them hasn’t reached the last eight at a major – opens up opportunities.

U.S. Open champion Stan Wawrinka, who had his major breakthrough here in 2014, is a growing contender after beating Andreas Seppi 7-6 (2), 7-6 (4), 7-6 (4). He’ll play a quarterfinal against 2008 Australian Open finalist Jo-Wilfried Tsonga, who beat Dan Evans 6-7 (4), 6-2, 6-4, 6-4.

On the other half of the draw, 14-time major winner Rafael Nadal is the only man still in contention who has won a Grand Slam title.

Zverev attacked Murray, unsettling his natural baseline game, and won 65 of 118 points at the net.

He made some stunning, lunging volleys on clutch points, but for him it was all a blur.

“Honestly, I don’t know, it was like I was in a little coma, I just served and volleyed my way through,” Zverev said. “Honestly there were a few points where I don’t know how I pulled it off.”

Murray couldn’t do a lot to counter it.

“It’s the shots he was coming up with when he did come forward.” Murray said. “I mean, he came up with some great pickups, you know, reflex volleys especially at the end when it was tight.

“He served very well when he needed to … he deserved to win because he played great when he was down, and also in the important moments.”

Seven-time major winner Venus Williams returned to the quarterfinals for the ninth time with a 6-3, 7-5 win over No. 181-ranked Mona Barthel.

She will next play No. 24-seeded Anastasia Pavlyuchenkova, who beat No. 8 Svetlana Kuznetsova 6-3, 6-3.

French Open champion Garbine Muguruza reached the quarterfinals in Australia for the first time, beating Sorana Cirstea 6-2, 6-3.

Murray had reached the quarterfinals or better on his previous seven trips to Melbourne Park – losing the finals in 2010 to Federer and in ’11, ’13, ’15 and ’16 to Djokovic.

He had not lost to a player ranked as lowly as Zverev at a major since his loss to No. 51 Juan Ignacio Chela here in 2006. It was also the earliest exit by a top-seeded player at the Australian Open since Lleyton Hewitt’s fourth-round departure in 2003.

The younger Zverev brother was in the crowd at Rod Laver, where the bulk of fans were pulling heavily for Murray as the fourth set began, shouting “Come on Andy!” after nearly every point.

Murray was agitated right from the start, hitting into the net early on and screaming loudly as glanced at his players’ box.

Serving at 4-3, Zverev hit two easy shots into the net, including a routine-looking overhead from Murray’s defensive lob, drawing gasps from the crowd.

But as he held on for what turned out to be the biggest win of the year, he gained support with daring play and frequent trips to the net.

After closing it out on his first match point, he walked calmly to the net and clasped his hands together in front of his chest, almost in relief.