NEW YORK, NY - SEPTEMBER 05:  Andy Murray of Great Britain celebrates defeating Grigor Dimitrov of Bulgaria during his fourth round Men's Singles match on Day Eight of the 2016 US Open at the USTA Billie Jean King National Tennis Center on September 5, 2016 in the Queens borough of New York City.  (Photo by Mike Stobe/Getty Images for USTA)
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U.S. Open Live Coverage: Day 10

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9:05 p.m.

Serena Williams and Simona Halep are heading to a third set in their U.S. Open quarterfinal.

Williams, seeded No. 1 and seeking her record-breaking 23rd Grand Slam title, took the opening set 6-2 on Wednesday night despite being broken for the first time in the tournament.

The No. 5-seeded Halep then saved seven break points in the second game of the second set, and broke Williams in the very next game to lead 2-1. Eventually, after saving all 12 break points she faced in that set, Halep grabbed it 6-4 on her fifth set point.

That is the first set Williams has lost in five matches at Flushing Meadows this year.

7:50 p.m.

A first-round U.S. Open women’s singles match will be looked into by tennis’ anti-corruption organization because of possible irregular betting patterns.

Tennis Integrity Unit spokesman Mark Harrison said Wednesday that 15th-seeded Timea Bacsinszky’s 6-1, 6-1 victory over Vitalia Diatchenko last week is the only match that has been the subject of an alert at Flushing Meadows this year.

U.S. Tennis Association spokesman Chris Widmaier said the tournament “is aware of the betting alert” and that the TIU is handling the mattter.

Widmaier added that “betting alerts need to be investigated, but they are certainly not gospel” and do not “necessarily indicate any nefarious doings.”

The New York Times first reported on the alert to the TIU.

6:15 p.m.

The U.S. Tennis Association says a digital audio sound processor at court level malfunctioned during the U.S. Open quarterfinal between Andy Murray and Kei Nishikori.

The second-ranked Murray dropped seven consecutive games after a let call caused by a loud noise from the malfunctioning equipment during a fourth-set point and lost to Kei Nishikori 1-6, 6-4, 4-6, 6-1, 7-5 on Wednesday.

Murray disagreed with chair umpire Marija Cicak’s decision to immediately halt things when play was interrupted by a sound similar to that of a gong being struck. It happened with Murray already up two sets to one and holding a second break point at 1-all in the fourth.

Murray complained about the ruling right away, gave away the next three points to lose the game, then brought it up again with Cicak at the ensuing changeover, saying something similar had happened earlier without a re-do of the point.

The USTA says the malfunctioning unit will be replaced between Wednesday’s day and night sessions.

6:10 p.m.

Andy Murray dropped seven consecutive games after a let call caused by a loud noise in the arena’s speaker system during a fourth-set point and lost to Kei Nishikori 1-6, 6-4, 4-6, 6-1, 7-5 in the U.S. Open quarterfinals on Wednesday.

Murray, the No. 2 seed and 2012 champion at Flushing Meadows, disagreed with chair umpire Marija Cicak’s decision to immediately halt things when play was interrupted by a sound similar to that of a gong being struck. It happened with Murray already up two sets to one and holding a second break point at 1-all in the fourth.

Murray complained about the ruling right away, gave away the next three points to lose the game, then brought it up again with Cicak at the ensuing changeover, saying something similar had happened earlier without a re-do of the point.

Nishikori was the 2014 runner-up at Flushing Meadows.

5:05 p.m.

Andy Murray was bothered by the chair umpire’s decision to call a let on a loud noise that came from the stadium’s speaker system and now finds himself headed to a fifth set against Kei Nishikori in the U.S. Open quarterfinals.

Murray led two sets to one – 6-1, 4-6, 6-4 – and held break points at 1-all in the fourth Wednesday. But during that second break chance, the point was interrupted by a noise something akin to a gong being struck. Chair umpire Marija Cicak immediately halted play. Murray complained about that right away, then again at the ensuing changeover, when he also spoke to a tournament supervisor.

He wound up losing 12 of 14 points right after the let call and five games in a row to drop that set 6-1.

1:20 p.m.

Karolina Pliskova dominated with her serve to roll past 18-year-old Ana Konjuh and into the U.S. Open semifinals.

The 10th-seeded Pliskova won 6-2, 6-2 in just 57 minutes Wednesday, losing only one point on her serve in the first set. She’ll face No. 1 Serena Williams or fifth-seeded Simona Halep on Thursday.

The 24-year-old Czech came into the U.S. Open with the distinction of being the only woman in the top 20 to never reach a Grand Slam round of 16. Now she’s blown past that milestone, riding the momentum of a breakthrough title at Cincinnati, where she beat second-ranked Angelique Kerber in the final.

The 92nd-ranked Konjuh hadn’t been past the third round at a major before this tournament. Also a big server, she had more aces than Pliskova on Wednesday, but she was broken four times and made 27 unforced errors.

12 p.m.

The last spots in the U.S. Open semifinals will be decided Wednesday, with Serena Williams, Andy Murray and Juan Martin del Potro seeking to keep their dominant runs going.

The top-seeded Williams, who hasn’t lost a set or had her serve broken in the tournament so far, faces No. 5-seeded Simona Halep. Williams has won seven of their last eight meetings.

The other women’s quarterfinal pits two women who’ve never been this far before at a Grand Slam tournament: 10th-seeded Karolina Pliskova of the Czech Republic and 92nd-ranked Ana Konjuh of Croatia.

On the men’s side, four of the tour’s best hard-court players meet in the last two men’s quarterfinals, with the No. 2-seeded Murray facing No. 6 Kei Nishikori in the afternoon, and No. 3 Stan Wawrinka taking on del Potro at night. Murray has dropped only one set in the tournament, and del Potro has lost none.

The roof on Arthur Ashe Stadium is currently open under partly cloudy skies, with a chance of rain in the afternoon.

Murray turns ankle during win

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MELBOURNE, Australia (AP) The Latest on Wednesday from the Australian Open (all times local):

10:50 p.m.

Top-seeded Andy Murray tumbled to the ground and hurt his right ankle early in the third set of his second-round win over Andrey Rublev at the Australian Open on Wednesday night.

He spoke to the trainer after that game, but didn’t need medical attention and went on to win 6-3, 6-0, 6-2.

A five-time runner-up at the season’s first major, Murray caught the sole of his right shoe on the court and tripped to the ground during the third game. He clutched his right ankle as he rolled on to the court and later was checked out by an ATP trainer during a medical time out.

After taking a 4-1 lead in the final set, Murray went to his courtside chair and said: “I’m all right.”

“It’s a little bit sore, not too serious,” he said in his post-match interview. “I definitely rolled it (but) I was moving OK toward the end, so that’s positive.”

9:35 p.m.

Andreas Seppi rallied from two sets down and saved a match point to beat an unpredictable Nick Kyrgios 1-6, 6-7 (1), 6-4, 6-2, 10-8 in a second-round match Wednesday at the Australian Open.

No. 14-seeded Kyrgios was broken in the 11th game of the final set. Serving for the match at 6-5, Seppi was broken in a game that started with a high-risk, between-the-legs shot by Kyrgios. The Australian won the point.

Two games later, Seppi saved a match point with a stunning forehand down the line and then held. The pressure was back on Kyrgios, who double-faulted on break point to hand Seppi a 9-8 lead.

The 89th-ranked Seppi clinched 3 hour, 9 minute match with an ace in the next game.

Kyrgios, tipped to have all the talent to win a Grand Slam title but not the temperament, was suspended by the ATP Tour following the Shanghai Masters in October when he sped through a match against Mischa Zverev with little effort or apparent care whether he won or lost.

Krygios was fined more than US$40,000 and suspended for eight weeks, a period that was later reduced to three when he agreed to consult with a sports psychologist.

8:55 p.m.

French Open champion Garbine Muguruza has advanced to the third round at the Australian Open with a 7-5, 6-4 win over American Samantha Crawford. Muguruza clinched the match on her first match point when Crawford netted a forehand.

The Spaniard will play Anastasija Sevastova in the third round.

6:35 p.m.

It’s been a disappointing day for the American men at Melbourne Park.

John Isner, the highest-seeded U.S. player in the men’s draw, wasted a two-set-to-none lead and lost in the second round to Mischa Zverev of Germany, 6-7 (4), 6-7 (4), 6-4, 7-6 (7), 9-7.

Isner had 98 winners in the 4-hour, 10-minute match, but only converted one of 17 breakpoint chances against Zverev.

Isner was joined on the sidelines by Steve Johnson, Noah Rubin and Ryan Harrison – all second-round losers on Wednesday afternoon.

The one bright spot for the U.S. was 31st-seeded Sam Querrey, who advanced with a 7-6 (5), 6-0, 6-1 win over Australian wild card Alex De Minaur.

Jack Sock, the 23rd seed, was playing later against Karen Khachanov of Russia.

5:35 p.m.

After winning the first two sets of his second-round match, Roger Federer had to really go to work in the third, recovering from 5-2 down and fending off two set points to defeat American qualifier Noah Rubin 7-5, 6-3, 7-6 (3).

He held serve at love to force the tiebreaker and, after it got to 3-3, reeled off the last four points to clinch the match in 2 hours, 4 minutes.

Federer is a four-time Australian Open champion but hasn’t lifted the trophy since 2010. In 18 trips to Melbourne Park, he’s never failed to reach the third round.

5:15 p.m.

Eugenie Bouchard is back in the third round at Melbourne Park for the first time in two years, defeating China’s Peng Shuai 7-6 (5), 6-2.

Bouchard, who reached the semifinals of the Australian Open in 2014, finally closed it out after Peng saved three match points on the Canadian’s serve at 5-1 in the second set.

Following her break-out year in 2014, which also saw her reach the Wimbledon final, Bouchard struggled to make it past the fourth round at the slams. Her best result last year was the third round at Wimbledon.

Her next opponent will be either CoCo Vandeweghe or Pauline Parmentier, who played later Wednesday.

“Overall, I’m feeling better with each passing day,” Bouchard said.

4:35 p.m.

Fourth-seeded Stan Wawrinka is into the third round of the Australian Open for the ninth consecutive year after a 6-3, 6-4, 6-4 win over American Steve Johnson on Wednesday.

Wawrinka won his first Grand Slam title at Melbourne Park in 2014 and has followed that up with two more majors – the French Open in 2015 and the U.S. Open last year.

The 31-year-old Wawrinka labored through five sets to win his first-round match against Martin Klizan in 3 hours, 24 minutes. He had a much easier time in the second round, beating Johnson in 1 hour, 52 minutes.

Wawrinka will next play either Viktor Troicki or Paolo Lorenzi.

3:15 p.m.

Defending champion Angelique Kerber marked her 29th birthday – angrily at times – with a 6-2, 6-7 (3), 6-2 win Wednesday over fellow German Carina Witthoeft.

Kerber, who beat Serena Williams in the Australian Open final last year, then won the U.S. Open in September, was her own worst enemy in the tiebreaker, double-faulting twice to turn a 3-2 lead into a 4-3 deficit.

Witthoeft, who had won a long rally which caused Kerber to swipe her racket toward the court just ahead of the double faults, won the next three points to level the match.

Kerber also started poorly in the third set, dropping her service, but rebounded to take a 4-1 lead, saving two break points in the fifth game, before closing out the match in 2 hours, 8 minutes.

She will next play the winner of Wednesday’s second-round match between Kristyna Pliskova and Irina-Camelia Begu.

1:55 p.m.

Serena and Venus Williams have pulled out of their scheduled first-round doubles match because of a right elbow injury to Venus, who won her singles match earlier Wednesday in straight sets over Stefanie Voegele.

The Williams sisters were set to play Timea Babos and Anastasia Pavlyuchenkova in a Show Court 2 match on Wednesday afternoon. The Australian Open confirmed the withdrawal on social media.

The American pair also withdrew from their first-round doubles match in 2015 at Melbourne Park.

The Williams sisters have won 14 Grand Slam doubles titles together, including four at the Australian Open.

1:20 p.m.

Kei Nishikori advanced to the third round in a far more straightforward manner than his five-set opener earlier this week.

The fifth-seeded Nishikori defeated Frenchman Jeremy Chardy 6-3, 6-4, 6-3 in just over two hours to reach the third round for the seventh consecutive year.

On Monday, he needed 3 1-2 hours before beating Andrey Kuznetsov in the first round.

“(I) was definitely playing much better than first round today,” he said Wednesday. “There were many ups and downs, still too many break points for me. Great to finish in three sets.”

Nishikori has reached the quarterfinals three times at Melbourne Park, but has never advanced beyond that stage. He could play top-seeded Andy Murray in the quarterfinals this year.

12:40 p.m.

Venus Williams, a first-round loser in 2016 at Melbourne Park, is one of the first players into the third round this year after beating Stefanie Voegele 6-3, 6-2 to begin play at Rod Laver Arena on Wednesday.

Williams maintained a perfect 3-0 record against the Swiss player, having beaten her on clay at Madrid, grass at Wimbledon and now hard courts in the year’s first Grand Slam tournament.

Voegele wasn’t helped by four double-faults in the opening set. In the second, Williams broke Voegele’s service with a blistering forehand to the open court to take a 3-1 lead, then broke her serve again in the final game.

Williams lost to eventual semifinalist Johanna Konta in the opening round last year.

The older sister of Serena Williams, Venus Williams has never won the Australian Open. She lost the 2003 final to Serena. Venus’ best recent finish here was a quarterfinal appearance in 2015.

11:15 a.m.

Defending champion Angelique Kerber and top-seeded Andy Murray play their second-round matches on Wednesday in much more pleasant temperatures at Melbourne Park.

A cool change hit the city overnight, dropping temperatures from 38 Celsius (100 Fahrenheit) on Tuesday afternoon to about 20 Celsius (68 Fahrenheit) when play began Wednesday.

Venus Williams was first up on Rod Laver Arena, playing Stefanie Voegele of Switzerland. Kerber was to follow against fellow German Carina Witthoeft, followed by Roger Federer against American qualifier Noah Rubin.

Murray was scheduled to play the last match on Wednesday night at Rod Laver.

Venus and Serena Williams were scheduled to play their opening doubles match on Wednesday afternoon.

Seppi posts comeback win over Kyrgios

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MELBOURNE, Australia (AP) The audacious between-the-legs shot by Nick Kyrgios. His missed match point. The nerveless break when Andreas Seppi was serving for a second-round upset win.

Three days into the Australian Open, Seppi’s 1-6, 6-7 (1), 6-4, 6-2, 10-8 comeback win Wednesday over the enigmatic Kyrgios rated as the match of the tournament.

Purely for talking points, it’ll be hard to beat.

The night match on a crowded Hisense Arena featured a stunning down-the-line forehand winner from Seppi to save a match point in the fifth set.

Two games earlier, when Seppi was serving for the match, an apparently nonchalant Kyrgios hit a ‘tweener’ from near the baseline, defying tennis wisdom. He won the point, and it will feature on highlight clips. But the No. 14-seeded Kyrgios missed a bigger opportunity at his home Grand Slam.

The 21-year-old Australian was broken in the 11th game of the fifth set. Serving for the match at 6-5, Seppi was broken in a game that started with that unusual Kyrgios shot.

Seppi, who have his 33rd birthday next month, subsequently saved a match point with the forehand down the line. He later explained it was a shot he had “missed a hundred times in practice (but) I made it today in an important moment.”

He held serve, returning the pressure to Kyrgios. A quarterfinalist at Wimbledon in 2014 and the Australian Open in 2015, Kyrgios double-faulted on break point to hand Seppi a 9-8 lead.

The 89th-ranked Seppi duly clinched the 3-hour, 9-minute match with an ace.

Kyrgios, who sustained a knee injury playing basketball several weeks ago, was circumspect about the loss.

“It’s obviously disappointing, but it was ultimately a pretty fun match,” Kyrgios said. “He’s a great guy and he deserved it, so… I’m not going to beat myself up about it. It could have gone either way.”

Kyrgios, tipped to have all the talent to win a Grand Slam title but not the temperament, was suspended by the ATP Tour following the Shanghai Masters last October when he sped through a match against Mischa Zverev with little effort or apparent care whether he won or lost.

Krygios was fined more than US$40,000 and suspended for eight weeks, a period that was later reduced to three when he agreed to consult with a sports psychologist. He said Wednesday he’s still seeing the psychologist and “it’s going very well.”

His on-court demeanor has divided public opinion. On Wednesday, he was mostly on his best behavior, except for some shouts to his courtside box.

There were some boos from the crowd at the end, and Krygios noticed.

“Obviously it’s not the greatest thing to hear,” he said. “I didn’t have the best preparation coming into the Australian Open. Pretty banged up, my body. But getting booed off, definitely not the best feeling.”

He said his knee issues would likely force him to pull out of doubles with his partner Daniel Evans.

Seppi had a match point against Kyrgios two years ago but lost. He settled the score in Melbourne, and will advance to the third round against Steve Darcis.

“He played a few good points, especially the first one, the tweener, I didn’t expect that,” Seppi said. “It was important to keep on going, keep focusing.

“The last time I was two sets to love up and I lost … and I just kept telling myself `keep fighting.’ I don’t know, maybe it was meant to be.”